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高锦豪

2011年05月24日

教授
办公室:卢嘉锡楼528 
电话:2180278 
Email:jhgao@xmu.edu.cn
通讯地址:厦门大学固体表面物理化学国家重点实验室
个人简历
  • 厦门大学教授 (2010 - )
  • 斯坦福大学博士后 (2008 - 2010)
  • 香港科技大学博士 (2008)
  • 南京大学学士 (2004)

 

研究兴趣

生物无机纳米材料,表界面化学,生物物理化学和分子影像学。

 

研究方向
  • 高性能磁共振造影材料
  • 氧化铁表界面结构与磁共振造影性能的构效关系
  • 纳米-生物界面研究
  • 药物输送体系
  • 癌症诊断和治疗


主要代表论文
  1. Zhou, Z. J.; Zhao, Z. H.; Zhang, H.; Wang, Z. Y.;  Chen, X. Y.; Wang, R. F.; Chen, Z.; Gao, J. H.* Interplay between Longitudinal and Transverse Contrasts in Fe3O4 Nanoplates with (111) Exposed Surfaces. ACS Nano 2014, 8, 7976-7985.
  2. Zhu, X. L.; Hu, J; Chi, X. Q.; Sun, M. J.; Wang, X. M.; Gao, J. H.* Kinetic and Sensitive Analysis of Tyrosinase Activity Using Electron Transfer Complexes: In Vitro and Intracellular Study. Small 2014, in press.
  3. Huang, G. M.; Li, H; Chen, J. H.; Zhao, Z. H.; Yang, L. J.; Chi, X. Q.; Chen, Z.; Wang, X. M.; Gao, J. H.* Tunable T1 and T2 Contrast Abilities of Manganese-engineered Iron Oxide Nanoparticles through Size Control. Nanoscale 2014, 6, 10404-10412.
  4. Huang, G. M.; Hu, J; Zhang, H.; Zhou, Z. J.; Chi, X. Q.; Gao, J. H.* Highly Magnetic Iron Carbide Nanoparticles as Effective T2 Contrast Agents. Nanoscale 2014, 6, 726-730.
  5. Zhao, Z. H.; Zhou, Z. J.; Bao, J. F.; Wang, Z. Y.; Hu, J.; Chi, X. Q.; Ni, K. Y.; Wang, R. F.; Chen, X. Y.; Chen, Z.; Gao, J. H.* Octapod Iron Oxide Nanoparticles as High-performance T2 Contrast Agents for Magnetic Resonance Imaging. Nat. Commun. 2013, 4, 2266.
  6. Zhou, Z. J.; Wang, L.R.; Chi, X. Q.; Bao, J. F.; Yang, L. J.; Zhan, W. X.; Chen, Z.; Wang, X. M.; Chen, X. Y.; Gao, J. H.* Engineered Iron-oxide-based Nanoparticles as Enhanced T1 Contrast Agents for Efficient Tumor Imaging. ACS Nano 2013, 7, 3287-3296.
  7. Zhou, Z. J.; Huang, D. T.; Bao, J. F.; Chen, Q. L.; Liu, G.; Chen, Z.; Chen, X. Y.; Gao, J. H.* A Synergistically Enhanced T1-T2 Dual-Modal Contrast Agent. Adv. Mater. 2012, 24, 6223-6228.
  8. Zhao, Z. H.; Huang, D. T.; Yin, Z. Y.; Chi, X. Q.; Wang, X. M.; Gao, J. H.* Magnetite Nanoparticles as Smart Carriers to Manipulate the Cytotoxicity of Anticancer Drugs: Magnetic Control and pH-Responsive Release. J. Mater. Chem. 2012, 22, 15717-15725.
  9. Chi, X. Q.; Huang, D.T.; Zhao, Z. H.; Zhou, Z. J.; Yin, Z. Y.; Gao, J. H.* Nanoprobes for In Vitro Diagnostics of Cancer and Infectious Diseases. Biomaterials 2012, 33, 189-206.
  10. Wei, Z. H.; Zhou, Z. J.;Yang, M.; Lin, C. H.; Zhao, Z. H.; Huang, D. T.; Chen, Z.; Gao, J. H.* Multifunctional Ag@Fe2O3 Yolk--shell Nanoparticles for Simultaneous Capture, Kill, and Removal of Pathogen. J. Mater. Chem. 2011, 21, 16344-16348.
  11. Gao, J. H.; Chen, K.; Luong, R.; Bouley, D. M.; Mao, H.; Qiao, T.; Gambhir, S. S.; Cheng, Z.* A Novel Clinically Translatable Fluorescent Nanoparticle for Targeted Molecular Imaging of Tumors in Living Subjects. Nano Lett. 2012, 12, 281-286.
  12. Gao, J. H.; Chen, K.; Miao, Z.; Ren, G.; Chen, X. Y.; Gambhir, S. S.; Cheng, Z.* Affibody-Based Nanoprobes for HER2-Expressing Cell and Tumor Imaging. Biomaterials 2011, 32, 2141-2148.
  13. Gao, J. H.*; Chen, K.; Xie, R. G.; Xie, J.; Lee, S.; Cheng, Z.; Peng, X. G.; Chen, X. Y.* Ultrasmall Near-infrared Non-cadmium Quantum Dots for in vivo Tumor Imaging. Small 2010, 6, 256-262.
  14. Gao, J. H.*; Chen, K.; Xie, R. G.; Xie, J.; Yang, Y. J.; Cheng, Z.; Peng, X. G.; Chen, X. Y.* In vivo Tumor-targeted Fluorescence Imaging Using Near-infrared Non-cadmium Quantum Dots. Bioconjugate Chem. 2010, 21, 604-609.
  15. He, X. X.#; Gao, J. H.#; Gambhir, S. S.; Cheng, Z.* Near-Infrared Fluorescent Nanoprobes for Cancer Molecular Imaging: Status and Challenges. Trends in Molecular Medicine 2010, 16, 574-583. (#equal contribution)
  16. Gao, J. H.; Gu, H. W.; Xu, B.* Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications. Acc. Chem. Res. 2009, 42, 1097-1107.
  17. Gao, J. H.; Xu, B.* Applications of Nanomaterials Inside Cells. Nano Today 2009, 4, 37-51.
  18. Gao, J. H.; Liang, G. L.; Cheung, S. C.; Pan, Y.; Kuang, Y.; Zhao, F.; Zhang, B.; Zhang, X. X.; Wu, E. X.; Xu, B.* Multifunctional Yolk-shell Nanoparticles: A Potential MRI Contrast and Anticancer Agent. J. Am. Chem. Soc. 2008, 130, 11828-11833.
  19. Gao, J. H.; Zhang, W.; Huang, P. B.; Zhang, B.; Zhang, X. X.; Xu, B.* Intracellular Control of Fluorescent Magnetic Nanoparticles. J. Am. Chem. Soc. 2008, 130, 3710-3711.
  20. Gao, J. H.; Zhang, B.; Gao, Y.; Pan, Y.; Zhang, X. X.; Xu, B.* Fluorescent Magnetic Nanocrystals by Sequential Addition of Reagents in a One-Pot Reaction: A Simple Preparation for Multifunctional Nanostructures. J. Am. Chem. Soc. 2007, 129, 11928-11935.
  21. Gao, J. H.; Liang, G. L.; Zhang, B.; Kuang, Y.; Zhang, X. X.; Xu, B.* FePt@CoS2 Yolk-shell Nanocrystals as a Potent Agent to Kill HeLa Cells. J. Am. Chem. Soc. 2007, 129, 1428-1433.
  22. Gao, J. H.; Li, L. H.; Ho, P. L.; Mak, G. C.; Gu, H. W.; Xu, B.* Combining Fluorescent Probes and Biofunctional Magnetic Nanoparticles for Rapid Detection of Bacteria in Human Blood. Adv. Mater. 2006, 18, 3145-3148.
  23. Gao, J. H.; Zhang, B.; Zhang, X. X.; Xu, B.* Magnetic Dipolar Interaction Induced Self-Assembly Affords Wires of Cobalt Selenide Hollow Nanoscrystals. Angew. Chem., Int. Ed. 2006, 45, 1220-1223.
研究组成员
  • 博士生:黄登通,赵征寰,周子健,黄国明,杨丽娇,朱祥龙,王俪蓉,孙乘杰
  • 硕士生:张慧,李辉,张宗珺,刘晗玉,周华璐
  • 毕业生:胡娟
获奖情况
  • 2007年获香港科学会颁发香港“青年科学家奖”
  • 2010年入选教育部“新世纪优秀人才支持计划”
  • 2011年被聘为福建省“闽江学者”特聘教授
  • 2012年“青年科学之星”
  • 2012年获国家基金委优秀青年科学基金资助
  • 2013年获福建省杰出青年科学基金资助
目前承担课题
  • 国家重大科学研究计划子课题:可控特性纳米材料的设计合成及其诱导自噬的相关性研究
  • “973”项目课题(学术骨干):乳腺癌分子分型标志物的多功能分子探针研究
  • 国家自然科学基金优秀青年科学基金:生物功能无机纳米材料
  • 国家自然科学基金面上项目:高性能磁性纳米药物的构建及其肿瘤诊疗一体化应用研究
  • 国家自然科学基金重点项目(第二负责人):以肝癌干细胞为靶标的多模态成像导航在肝癌介入治疗的研究
  • 福建省杰出青年科学基金:多功能智能纳米药物控释系统的基础研究
  • 霍英东基金会青年教师基金应用研究课题:纳米生物医用材料的肿瘤诊疗应用研究