首页> 队伍成员>杨朝勇

杨朝勇

2011年11月09日

教授
办公室:卢嘉锡楼532 
电话:2187601 
Email:cyyang@xmu.edu.cn
通讯地址:厦门大学固体表面物理化学国家重点实验室
个人简历
  • 厦门大学教授(2008- )
  • 美国加州大学伯克利分校博士后 (2006-2007)
  • 美国佛罗里达大学博士(2001-2006)
  • 厦门大学学士、硕士(1994-2001)

 

研究兴趣
  • 特异性生物分子识别研究;
  • 微流控技术在生物医学中的应用;
  • 纳米生物医学工程;
  • DNA纳米组装和信号放大;
  • 单细胞研究技术。

 

主要代表论文

 1.    Yan, L; Zhu, Z; Zou, Y; Huang, Y; Liu, D; Jia, S; Xu, D; Wu, M; Zhou, Y; Zhou, S; Yang, C*, Target-repsonsive “Sweet” Hydrogel with Glucometer Readout: an Effective Method for Portable and Quantitative Detection of Non-glucose Targets, J. Am. Chem. Soc., 2013, DOI: 10.1021/ja3114714

2.    Cui, L; Chen, Z; Zhu, Z; Xiaoyan Lin; Chen, X; Yang, C*, Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way to Design Highly Robust RNA Probes, Anal Chem, 2013, DOI: 10.1021/ac303179z

3.    Xiong, X; Liu, H; Zhao, Z; Altman, M; Lopez-Colon, D; Yang, C*, Chang, L; Liu, C; Tan, W*; DNA Aptamer-mediated Cell Targeting, Angew. Chem. Int. Ed Engl. 2013, DOI: 10.1002/anie.201207063

4.    Ke, G; Wang, C; Ge Y; Zheng, N; Zhu Z; Yang, C*, L-DNA Molecular Beacons: A Safe, Stable, and Accurate Intracellular Nano-thermometer for Temperature Sensing in Living Cells, J. Am. Chem. Soc., 2012, 134, 18908−18911

5.    Zhu, L; Li, C; Zhu, Z; Zou, Y; Fu, H; Wang, C; Yang, C*, In Vitro Selection of Highly Efficient G-Quadruplex-Based DNAzymes, Anal Chem, 2012,84(19):8383-8390

6.    Wu, J; Wang, C; Li, X; Song, Y; Wang, W; Li, C; Hu, J; Zhu Z*; Zhang, W; Lu Z*; Yang, C*, Identification, Characterization and Application of a G-quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2, PLoS ONE, 2012, 7(9): e46393

7.    Zhao, X; Wu, J; Liang, J; Yan, J; Zhu, Z; Yang, C*; Mao, B*, Single-Molecule Force Spectroscopic Studies on Intra- and Inter-Molecular Interactions of G-Quadruplex Aptamer with Target Shp2 Protein,J Physic Chem B, 2012, 116(37):11397-404

8.    Zhou, T; Huang, Y; Li W; Cai, Z; Luo F; Yang, C*; Chen X*, Facile synthesis of red-emitting lysozyme-stabilized Ag nanoclusters, Nanoscale 2012, 4, 5312–5315

9.    Kang, D*; Wang, J; Zhang, W; Zhu, M; Zhu, Z;; Yang, C*, Selection of DNA Aptamers against Glioblastoma Cells with High Affinity and Specificity, PLoS ONE, 2012, 7(10): e42731

10. Li, C; Zhu, L; Zhu, Z; Fu, H; Jenkins, G; Wang, C; Zou, Y; Lu, X; Yang, C*, Backbone Modification Promotes Peroxidase Activity of G-Quadruplex-Based DNAzyme, Chem. Commun., 2012, 48 (67), 8347 – 8349

11. Zhu, Z; Zhang, W; Leng, X; Zhang, M; Guan, Z, Yang, C*, Highly Sensitive and Quantitative Detection of Rare Pathogen through Agarose Droplet Microfluidic Emulsion PCR at the Single-Cell Level, Lab Chip 2012, 12 (20), 3907 - 3913.

12. Cui, L; Zou, Y; Lin, N; Zhu, Z; Jenkins, G; Yang, C* , Mass Amplifying Probe for Sensitive Fluorescence Anisotropy Detection of Small Molecules in Complex Biological Samples, Anal Chem, 2012, 84 (13),5535-5541

13. Zhang, H; Jenkins, G; Zou, Y; Zhu, Z; Yang, C* , Massively Parallel Single-Molecule and Single-Cell Emulsion Reverse Transcription Polymerase Chain Reaction Using Agarose Droplet Microfluidics, Anal Chem, 2012, 84 (8), 3599–3606

14. Zhang, W; Zhang, W; Liu, Z; Li, C; Zhu, Z; Yang, C*, A Highly Parallel Single Molecule Amplification Approach Based on Agarose Droplet PCR for Efficient and Cost-effective Aptamer Selection, Anal Chem, 2012, 84 (1), 350–355

15. Song, Y; Zhang, W; An, Y; Cui, L; Chen, X; Zhu, Z*; Yang, C*, Label-Free Visual Detection of Nucleic Acids in Biological Samples with Single-Base Mismatch Detection Capability, Chem. Commun., 2012, 48, 576-578

16. Cui, L; Lin, X; Lin, N; Song, Y; Zhu, Z; Chen, X; Yang, C*, Graphene Oxide -Protected DNA Probes for Multiplex MicroRNA Analysis in Complex Biological Samples Based on Cyclic Enzymatic Amplification Method, Chem. Commun., 2012, 48, 194-196 (Inside Cover)

17. Song, Y.; Cui, L.; Wu, J.;Zhang, W.; Kang, H.; Yang, C.*, Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins and Small Molecules in Complex Biological Samples, Chem.-Eur. J., 2011,17, 9042-9046.(Inside Cover)

18. Lin, H.; Zou, Y.; Huang, Y.; Chen, J.; Zhang, W.; Zhuang, Z.; Jenkins, G.; Yang, C.*; DNAzymeCrosslinkedHydrogel: ANew Platform for Visual Detection of Metal Ions, Chem. Commun., 2011, 47, 9312–9314.(Back Cover)

19. Wang, K.; You, M.; Chen, Y.; Han, D.; Zhu, Z. Huang, J.;Williams, K.; Yang, C.*; Tan, W.* ; Self-assembly of a Bifunctional DNA Carrier for DrugDelivery, Angew. Chem. Int. Ed Engl. 2011,50, 27,6098–6101.

20. Wang, C.; Zhu, Z.; Song, Y.; Lin H.; Yang C.*; Tan, W*;Caged molecular beacons: controlling nucleic acid hybridizationwith light, Chem. Commun.,2011,47 (20), 5708 - 5710

21. Huang, J.; Wu, Y.; Chen, Y.;, Zhu, Z.; Yang, X.; Yang, C.*; Wang, K.*; Tan, W.*; PyreneExcimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification, Angew. Chem. Int. Ed Engl. 2011,50,401-404

22. Chen, Y.; O'Donoghue, M.; Huang, Y.; Kang, H.; Phillips, J.; Chen, X; Estevez, M.; Yang, C.; Tan, W.*,A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces, J. Am. Chem. Soc., 2010, 132 (46), 16559–16570.

23. Leng, X.; Zhang, W.; Wang, C.; Cui, L,; Yang, C.*, Agarose Droplet Microfluidics for Highly Parallel and EfficientSingle Molecule Emulsion PCR, Lab Chip 2010,10 (21), 2841-2843. (Inside Cover),(Top Ten Accessed Paper, 2010 September)

24. Zhu, Z.; Wu C.; Liu H.; Zou Y.; Zhang X.; Kang H.; Yang C.*; Tan W.*, Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection. Angew. Chem. Int. Ed Engl. 2010,49(2)1052 –1056.(Frontipiece Paper)

25. Zhang, W.; Lin, S.; Wang, C.; Hu, J.; Li, C.; Zhuang, Z.; Zhou, Y.; Mathies, R. A.*; Yang, C.* PMMA/PDMS valves and pumps for disposable microfluidics. Lab Chip 2009,9 (21), 3088-3094.

26. Wang, K.; Tang, Z.; Yang, C.; Kim, Y.; Fang, X.; Li, W.; Wu, Y.; Medley, C. D.; Cao, Z.; Li, J.; Colon, P.; Lin, H.; Tan, W. Molecular engineering of DNA: molecular beacons. Angew. Chem. Int. Ed Engl. 2009,48 (5), 856-870.

27. Kumaresan, P.; Yang, C.; Cronier, S. A.; Blazej, R. G.; Mathies, R. A. High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal. Chem. 2008,80 (10), 3522-3529.(Cover)(Co-First Author)

28. Wu, Y.; Yang, C.; Moroz, L. L.; Tan, W. Nucleic acid beacons for long-term real-time intracellular monitoring. Anal. Chem. 2008,80 (8), 3025-3028.

29. Conlon, P.; Yang, C.; Wu, Y.; Chen, Y.; Martinez, K.; Kim, Y.; Stevens, N.; Marti, A. A.; Jockusch, S.; Turro, N. J.; Tan, W. Pyrene excimer signaling molecular beacons for probing nucleic acids. J. Am. Chem. Soc. 2008,130 (1), 336-342.

30. Kim, Y.; Yang, C.; Tan, W. Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem. Nucleic Acids Res. 2007,35 (21), 7279-7287.

31. Yang, C.; Wang, L.; Wu, Y.; Kim, Y.; Medley, C. D.; Lin, H.; Tan, W. Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons. Nucleic Acids Res. 2007,35 (12), 4030-4041.

32. Yang, C.; Martinez, K.; Lin, H.; Tan, W. Hybrid molecular probe for nucleic acid analysis in biological samples. J. Am. Chem. Soc. 2006,128 (31), 9986-9987.

33. Yang, C.; Jockusch, S.; Vicens, M.; Turro, N. J.; Tan, W. Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc. Natl. Acad. Sci. U.S.A 2005,102 (48), 17278-17283.

34. Wang, L.; Yang, C.; Medley, C. D.; Benner, S. A.; Tan, W. Locked nucleic acid molecular beacons. J. Am. Chem. Soc. 2005,127 (45), 15664-15665.

35. Yang, C.; Lin, H.; Tan, W. Molecular assembly of superquenchers in signaling molecular interactions. J. Am. Chem. Soc. 2005,127 (37), 12772-12773.

36. Yang, C.; Pinto, M.; Schanze, K.; Tan, W. Direct synthesis of an oligonucleotide-poly(phenylene ethynylene) conjugate with a precise one-to-one molecular ratio. Angew. Chem. Int. Ed Engl. 2005, 44 (17), 2572-2576.

 

 

研究组成员

朱志 副教授

获奖情况
  • 福建省运盛青年科技奖(2013)
  •  中美化学与化学生物学教授协会“杰出教授奖”(Distinguished Faculty Award, 2012)
  •  厦门大学“工商银行奖教金”(2011)
  •  2005年度中国国家优秀自费留学生奖(2006)
  •  美国佛罗里达大学O’Neil 博士论文奖 (2005-2006)
  • 美国化学会分析化学研究生奖 (2005, 美国 默克公司资助)